Understanding the T cell immune response in SARS coronavirus infection

Understanding the T cell immune response in SARS coronavirus infection

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The severe acute respiratory syndrome (SARS) epidemic started in late 2002 and swiftly spread across 5 continents with a mortality rate biffy clyro vinyl offers of around 10%.Although the epidemic was eventually controlled through the implementation of strict quarantine measures, there continues a need to investigate the SARS coronavirus (SARS-CoV) and develop interventions should it re-emerge.Numerous studies have shown that neutralizing antibodies against the virus can be found in patients infected with SARS-CoV within days upon the onset of illness and lasting up to several months.In contrast, there is little data on the kinetics of T cell responses during SARS-CoV infection and little is known about their role in the recovery process.However, recent studies dwarf montmorency cherry tree for sale in mice suggest the importance of T cells in viral clearance during SARS-CoV infection.

Moreover, a growing number of studies have investigated the memory T cell responses in recovered SARS patients.This review covers the available literature on the emerging importance of T cell responses in SARS-CoV infection, particularly on the mapping of cytotoxic T lymphocyte (CTL) epitopes, longevity, polyfunctionality and human leukocyte antigen (HLA) association as well as their potential implications on treatment and vaccine development.Emerging Microbes & Infections (2012) 1, e23; doi:10.1038/emi.2012.

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